Women With Homozygous Sickle Cell Disease - 928 Words

Case Study: A 25-year-old women with homozygous sickle cell disease presented to tertiary center at 32 weeks’ gestation with weakness, fever, and worsening anemia. Her obstetric history included previous pregnancy post two years complicated with mild preeclampsia resulting in cesarean delivery at term, but had no reports of sickle cell complications like painful crisis, splenic sequestration or blood transfusion. On arrival she reported left upper abdominal pain, temperature 38oC, heart rate 115bpm, blood pressure of 120/80. Her spleen was palpable 4cm below left costal margin with tenderness. Laboratory results indicated hemoglobin 2.4g/dl and hematocrit 7.8%. Fetal monitoring was performed for 60 minutes, baseline fetal heart rate was 150 bpm with absence of variability and accelerations. At beginning of record a prolonged deceleration lasting four minutes was noted. The volume of amniotic fluid was normal and the fetal biophysical profile was 6. Two packs of red blood cells were immediately transfused, resulting in progression of fetal heart rate and biophysical profile to normal. Twelve hours after transfusion patient’s hemoglobin was 4.3g/dl and two additional packs of red blood cells were transfused. Twenty-four hours later patient’s hemoglobin was 5.9g/dl, and after one more additional unit of packed red blood cells her level increased to 7.4g/dl. The patient was kept in hospital with ultrasound indicating normal fetal growth and antenatal fetal surveillanceShow MoreRelatedAfrican American Parents With The Sickle Cell Trait1524 Words   |  7 PagesAfrican-American parents with the Sickle Cell Trait have the greatest risk of passing Sickle Cell Anemia to their offspring. In this article, sickle cell anemia is defined as a hereditary disease that destroys red blood cells by causing them take on an elongated and rigid sickle shape. In addition, a different type of hemoglobin called Hemoglobin S, is the protein in red blood cells that carry oxygen throughout the body. This protein starts to wrap around other red blood cells when oxygen is lacking toRead MoreGenetic Disorders1363 Words   |  6 Pagesis called the dominant gene and the less powerful is the recessive. A variation of a gene and the trait it controls, such as the color of ones eyes or hair is called in allele. Most diseases have genetic disorders. A diseases springs from genetics that are passed along from the parents. So called genetic diseases can be classified in 3 ways single gene defects, chromosomal disorders and multi factorial. 1 in 200 births have single gene defects. There are over 6000 different known single gene disordersRead More Genetic Disorders Essay1343 Words   |  6 Pagesand the less powerful is the recessive. A variation of a gene and the trait it controls, such as the color of ones eyes or hair is called in allele. nbsp;nbsp;nbsp;nbsp;nbsp;Most diseases have genetic disorders. A diseases springs from genetics that are passed along from the parents. So called genetic diseases can be classified in 3 ways single gene defects, chromosomal disorders and multi factorial. 1 in 200 births have single gene defects. There are over 6000 different known single gene disordersRead Moregenetics and heredity1693 Words   |  7 Pageschemical reactions in the body. Homozygous for a gene means that a person has an identical pair of genes on the two chromosomes. Heterozygous for a gene means that a person has an unmatched pair of genes on the two chromosomes Genes are either dominant, recessive, or intermediate. Examples: eye color, ability to taste PTC A dominant gene shows a strong effect in either the homozygous or heterozygous condition. A recessive gene shows its effect only in the homozygous condition. 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To this day, the disease continues to be one of the most important parasitic infections known to man. According to the World Health Organization, 3.4 million people may be considered at risk on a global scale and estimates indicate that there were 207 million cases in 2012 withRead MoreThe Historical Prevalence Of Bisexuality Essay1855 Words   |  8 Pagesbelief; a longitudinal study conducted by Rosario, Scrimshaw, Hunter Braun (2006) found that some youths who identified as bisexual at baseline, especially young men, eventually transitioned to identifying as homosexual. However, for the majority of women and for many men who identify as bisexual, this is not the case, and generalizing this finding to all members of the bisexual community is a form of erasu re (Rosario et al 2006). 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